
When they first meet, Ivy's toxic lips planted a seed of toxic rapture in Bruce. Ivy's first kiss was poison, the second its antidote. In one comic, Ivy was robbing a charity gala Bruce Wayne was attending. Pamela Isley aka Poison Ivy has been portrayed as a love interest for Batman in some comics. She is best known as a villain of Batman and plays an important role in his rogues gallery and has proven to be one of his more powerful foes.

Fellow villain Harley Quinn is her recurring partner-in-crime and possibly her only human friend. She uses toxins from plants and her own bloodstream for her criminal activities, which are usually aimed at protecting the natural environment. She is obsessed with plants, botany, and environmentalism. Poison Ivy is depicted as one of the world's most prominent eco-terrorists. She is not liked by the various members of the rogues gallery, but is greatly respected. She is known to have an occasional partnership/friendship with Harley Quinn. This incident with Dent causes a great rift between Ivy and Two Face, who has a great animosity toward her. After almost killing Dent with her poisonous lipstick, she is apprehended by Batman. When she sees then DA Harvey Dent destroy an endangered plant during the ground-breaking ceremony for Stone Gate Prison, he becomes the first object of her evil affections. The animated series introduces Poison Ivy as a botanist who works for a cosmetics company developing new fragrances.

She is known to use poison perfumes and lipstick as well as plant creatures of her own design. Her crimes are often targeted toward wealthy men.

She is evil yet can be incredibly seductive in luring men to do her bidding. Those who spurn or commit acts that harm plant life or the environment become the object of the evil affections of Poison Ivy. After learning she has a hyperactive immune system that causes her body reject any infection, poison, or outside contamination, she dons the guise of "Poison Ivy" and begins a career of crime. Pamela Lillian Isley was a well-known and highly successful botanist.
